| AID1794808 | Fluorescence-based screening to identify small molecule inhibitors of Plasmodium falciparum apicoplast DNA polymerase (Pf-apPOL). | 2014 | Journal of biomolecular screening, Jul, Volume: 19, Issue:6
| A High-Throughput Assay to Identify Inhibitors of the Apicoplast DNA Polymerase from Plasmodium falciparum. |
| AID1794808 | Fluorescence-based screening to identify small molecule inhibitors of Plasmodium falciparum apicoplast DNA polymerase (Pf-apPOL). | | | |
| AID588501 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set | 2010 | Current protocols in cytometry, Oct, Volume: Chapter 13 | Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening. |
| AID588501 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set | 2006 | Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5
| Microsphere-based protease assays and screening application for lethal factor and factor Xa. |
| AID588501 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set | 2010 | Assay and drug development technologies, Feb, Volume: 8, Issue:1
| High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors. |
| AID588499 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set | 2010 | Current protocols in cytometry, Oct, Volume: Chapter 13 | Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening. |
| AID588499 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set | 2006 | Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5
| Microsphere-based protease assays and screening application for lethal factor and factor Xa. |
| AID588499 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set | 2010 | Assay and drug development technologies, Feb, Volume: 8, Issue:1
| High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors. |
| AID651635 | Viability Counterscreen for Primary qHTS for Inhibitors of ATXN expression | | | |
| AID504810 | Antagonists of the Thyroid Stimulating Hormone Receptor: HTS campaign | 2010 | Endocrinology, Jul, Volume: 151, Issue:7
| A small molecule inverse agonist for the human thyroid-stimulating hormone receptor. |
| AID588497 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set | 2010 | Current protocols in cytometry, Oct, Volume: Chapter 13 | Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening. |
| AID588497 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set | 2006 | Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5
| Microsphere-based protease assays and screening application for lethal factor and factor Xa. |
| AID588497 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set | 2010 | Assay and drug development technologies, Feb, Volume: 8, Issue:1
| High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors. |
| AID504812 | Inverse Agonists of the Thyroid Stimulating Hormone Receptor: HTS campaign | 2010 | Endocrinology, Jul, Volume: 151, Issue:7
| A small molecule inverse agonist for the human thyroid-stimulating hormone receptor. |
| AID619988 | AUC (0 to last) in Swiss mouse brain at 10 mg/kg, po | 2011 | European journal of medicinal chemistry, Oct, Volume: 46, Issue:10
| Biophysical and physicochemical methods differentiate highly ligand-efficient human D-amino acid oxidase inhibitors. |
| AID620008 | Volume of distribution in Swiss mouse plasma at 1 mg/kg, iv | 2011 | European journal of medicinal chemistry, Oct, Volume: 46, Issue:10
| Biophysical and physicochemical methods differentiate highly ligand-efficient human D-amino acid oxidase inhibitors. |
| AID619923 | Kinetic solubility of the compound in 0.01 M phosphate buffered saline at pH 7.4 assessed as maximum solubility after 2 hrs | 2011 | European journal of medicinal chemistry, Oct, Volume: 46, Issue:10
| Biophysical and physicochemical methods differentiate highly ligand-efficient human D-amino acid oxidase inhibitors. |
| AID619986 | AUC (0 to last) in Wistar rat brain at 10 mg/kg, po | 2011 | European journal of medicinal chemistry, Oct, Volume: 46, Issue:10
| Biophysical and physicochemical methods differentiate highly ligand-efficient human D-amino acid oxidase inhibitors. |
| AID619984 | Cmax in Swiss mouse brain at 10 mg/kg, po | 2011 | European journal of medicinal chemistry, Oct, Volume: 46, Issue:10
| Biophysical and physicochemical methods differentiate highly ligand-efficient human D-amino acid oxidase inhibitors. |
| AID619994 | Oral bioavailability (0 to last) in Wistar rat plasma at 10 mg/kg | 2011 | European journal of medicinal chemistry, Oct, Volume: 46, Issue:10
| Biophysical and physicochemical methods differentiate highly ligand-efficient human D-amino acid oxidase inhibitors. |
| AID408638 | Inhibition of human DDO | 2008 | Bioorganic & medicinal chemistry letters, Jun-01, Volume: 18, Issue:11
| The discovery of fused pyrrole carboxylic acids as novel, potent D-amino acid oxidase (DAO) inhibitors. |
| AID619917 | Binding affinity to human recombinant DAAO assessed as drug-enzyme complex half life | 2011 | European journal of medicinal chemistry, Oct, Volume: 46, Issue:10
| Biophysical and physicochemical methods differentiate highly ligand-efficient human D-amino acid oxidase inhibitors. |
| AID1300693 | Inhibition of human recombinant DAAO using D-alanine as substrate assessed as pyruvate production incubated for 60 mins by microplate reader analysis | 2016 | European journal of medicinal chemistry, Jul-19, Volume: 117 | Discovery and analgesic evaluation of 8-chloro-1,4-dihydropyrido[2,3-b]pyrazine-2,3-dione as a novel potent d-amino acid oxidase inhibitor. |
| AID619992 | Ratio of drug level (0 to last) in brain to plasma in Swiss mouse at 10 mg/kg, po | 2011 | European journal of medicinal chemistry, Oct, Volume: 46, Issue:10
| Biophysical and physicochemical methods differentiate highly ligand-efficient human D-amino acid oxidase inhibitors. |
| AID1389531 | Inhibition of human DAAO using D-KYN as substrate preincubated for 20 mins followed by substrate addition measured after 30 mins by FP-6300-based fluorescence spectrometry | 2018 | Bioorganic & medicinal chemistry, 05-01, Volume: 26, Issue:8
| Discovery of isatin and 1H-indazol-3-ol derivatives as d-amino acid oxidase (DAAO) inhibitors. |
| AID620004 | Terminal half life in Swiss mouse brain at 10 mg/kg, po | 2011 | European journal of medicinal chemistry, Oct, Volume: 46, Issue:10
| Biophysical and physicochemical methods differentiate highly ligand-efficient human D-amino acid oxidase inhibitors. |
| AID620006 | Volume of distribution in Wistar rat plasma at 1 mg/kg, iv | 2011 | European journal of medicinal chemistry, Oct, Volume: 46, Issue:10
| Biophysical and physicochemical methods differentiate highly ligand-efficient human D-amino acid oxidase inhibitors. |
| AID1300691 | Inhibition of DAAO in porcine kidney homogenate using D-alanine as substrate assessed as pyruvate production incubated for 5 mins by microplate reader analysis | 2016 | European journal of medicinal chemistry, Jul-19, Volume: 117 | Discovery and analgesic evaluation of 8-chloro-1,4-dihydropyrido[2,3-b]pyrazine-2,3-dione as a novel potent d-amino acid oxidase inhibitor. |
| AID1171400 | Drug metabolism in mouse liver microsomes assessed as glucuronidation of compound measured as compound remaining after 60 mins by LC/MS analysis | 2014 | ACS medicinal chemistry letters, Nov-13, Volume: 5, Issue:11
| Structure-Metabolism Relationships in the Glucuronidation of d-Amino Acid Oxidase Inhibitors. |
| AID620002 | Terminal half life in Wistar rat brain at 10 mg/kg, po | 2011 | European journal of medicinal chemistry, Oct, Volume: 46, Issue:10
| Biophysical and physicochemical methods differentiate highly ligand-efficient human D-amino acid oxidase inhibitors. |
| AID371730 | Dissociation constant, pKa of the compound | 2009 | Journal of medicinal chemistry, Jun-11, Volume: 52, Issue:11
| Discovery, SAR, and pharmacokinetics of a novel 3-hydroxyquinolin-2(1H)-one series of potent D-amino acid oxidase (DAAO) inhibitors. |
| AID404690 | Increase in D-serine level in Sprague-Dawley rat prefrontal cortex at 30 mg/kg, po coadministered with D-serine | 2008 | Journal of medicinal chemistry, Jun-26, Volume: 51, Issue:12
| Synthesis and biological evaluation of D-amino acid oxidase inhibitors. |
| AID1389535 | Binding affinity to pig kidney DAAO by ITC method | 2018 | Bioorganic & medicinal chemistry, 05-01, Volume: 26, Issue:8
| Discovery of isatin and 1H-indazol-3-ol derivatives as d-amino acid oxidase (DAAO) inhibitors. |
| AID404688 | Inhibition of pig D-amino acid oxidase | 2008 | Journal of medicinal chemistry, Jun-26, Volume: 51, Issue:12
| Synthesis and biological evaluation of D-amino acid oxidase inhibitors. |
| AID620082 | Plasma clearance in Swiss mouse plasma at 1 mg/kg, iv | 2011 | European journal of medicinal chemistry, Oct, Volume: 46, Issue:10
| Biophysical and physicochemical methods differentiate highly ligand-efficient human D-amino acid oxidase inhibitors. |
| AID404689 | Increase in D-serine level in Sprague-Dawley rat plasma at 30 mg/kg, po coadministered with D-serine | 2008 | Journal of medicinal chemistry, Jun-26, Volume: 51, Issue:12
| Synthesis and biological evaluation of D-amino acid oxidase inhibitors. |
| AID619922 | Kinetic solubility of the compound in 0.01 M phosphate buffered saline at pH 7.4 assessed as minimum solubility after 2 hrs | 2011 | European journal of medicinal chemistry, Oct, Volume: 46, Issue:10
| Biophysical and physicochemical methods differentiate highly ligand-efficient human D-amino acid oxidase inhibitors. |
| AID620000 | Tmax in Swiss mouse brain at 10 mg/kg, po | 2011 | European journal of medicinal chemistry, Oct, Volume: 46, Issue:10
| Biophysical and physicochemical methods differentiate highly ligand-efficient human D-amino acid oxidase inhibitors. |
| AID404691 | Increase in D-serine level in Sprague-Dawley rat prefrontal cortex at 30 mg/kg, po | 2008 | Journal of medicinal chemistry, Jun-26, Volume: 51, Issue:12
| Synthesis and biological evaluation of D-amino acid oxidase inhibitors. |
| AID408637 | Inhibition of human DAO | 2008 | Bioorganic & medicinal chemistry letters, Jun-01, Volume: 18, Issue:11
| The discovery of fused pyrrole carboxylic acids as novel, potent D-amino acid oxidase (DAO) inhibitors. |
| AID619912 | Binding affinity to human recombinant DAAO by isothermal titration calorimeter analysis | 2011 | European journal of medicinal chemistry, Oct, Volume: 46, Issue:10
| Biophysical and physicochemical methods differentiate highly ligand-efficient human D-amino acid oxidase inhibitors. |
| AID619982 | Cmax in Wistar rat brain at 10 mg/kg, po | 2011 | European journal of medicinal chemistry, Oct, Volume: 46, Issue:10
| Biophysical and physicochemical methods differentiate highly ligand-efficient human D-amino acid oxidase inhibitors. |
| AID619924 | Apparent permeability across apical to basolateral side in human Caco2 cells by LC-MS/MS analysis | 2011 | European journal of medicinal chemistry, Oct, Volume: 46, Issue:10
| Biophysical and physicochemical methods differentiate highly ligand-efficient human D-amino acid oxidase inhibitors. |
| AID619915 | Inhibition of bovine recombinant DASPO expressed in Escherichia coli preincubated for 15 mins by fluorescence assay | 2011 | European journal of medicinal chemistry, Oct, Volume: 46, Issue:10
| Biophysical and physicochemical methods differentiate highly ligand-efficient human D-amino acid oxidase inhibitors. |
| AID620010 | Plasma clearance in Wistar rat plasma at 1 mg/kg, iv | 2011 | European journal of medicinal chemistry, Oct, Volume: 46, Issue:10
| Biophysical and physicochemical methods differentiate highly ligand-efficient human D-amino acid oxidase inhibitors. |
| AID619980 | Intrinsic clearance in human liver microsomes | 2011 | European journal of medicinal chemistry, Oct, Volume: 46, Issue:10
| Biophysical and physicochemical methods differentiate highly ligand-efficient human D-amino acid oxidase inhibitors. |
| AID619998 | Tmax in Wistar rat brain at 10 mg/kg, po | 2011 | European journal of medicinal chemistry, Oct, Volume: 46, Issue:10
| Biophysical and physicochemical methods differentiate highly ligand-efficient human D-amino acid oxidase inhibitors. |
| AID619990 | Ratio of drug level (0 to last) in brain to plasma in Wistar rat at 10 mg/kg, po | 2011 | European journal of medicinal chemistry, Oct, Volume: 46, Issue:10
| Biophysical and physicochemical methods differentiate highly ligand-efficient human D-amino acid oxidase inhibitors. |
| AID619914 | Binding affinity to human recombinant DAAO by steady state study scintillation proximity assay | 2011 | European journal of medicinal chemistry, Oct, Volume: 46, Issue:10
| Biophysical and physicochemical methods differentiate highly ligand-efficient human D-amino acid oxidase inhibitors. |
| AID619910 | Inhibition of human recombinant DAAO expressed in Escherichia coli assessed as H2O2 production from D-serine degradation after 30 mins by fluorescence assay | 2011 | European journal of medicinal chemistry, Oct, Volume: 46, Issue:10
| Biophysical and physicochemical methods differentiate highly ligand-efficient human D-amino acid oxidase inhibitors. |
| AID619919 | Octanol-water partition coefficient, log P of the neutral compound by pH-metric method | 2011 | European journal of medicinal chemistry, Oct, Volume: 46, Issue:10
| Biophysical and physicochemical methods differentiate highly ligand-efficient human D-amino acid oxidase inhibitors. |
| AID1300692 | Inhibition of rat spinal DAAO using D-alanine as substrate assessed as pyruvate production incubated for 60 mins by microplate reader analysis | 2016 | European journal of medicinal chemistry, Jul-19, Volume: 117 | Discovery and analgesic evaluation of 8-chloro-1,4-dihydropyrido[2,3-b]pyrazine-2,3-dione as a novel potent d-amino acid oxidase inhibitor. |
| AID619913 | Binding affinity to human recombinant DAAO by kinetic study scintillation proximity assay | 2011 | European journal of medicinal chemistry, Oct, Volume: 46, Issue:10
| Biophysical and physicochemical methods differentiate highly ligand-efficient human D-amino acid oxidase inhibitors. |
| AID619918 | Dissociation constant, pKa of the compound by dip probe absorption spectroscopy technique | 2011 | European journal of medicinal chemistry, Oct, Volume: 46, Issue:10
| Biophysical and physicochemical methods differentiate highly ligand-efficient human D-amino acid oxidase inhibitors. |
| AID619916 | Inhibition of human ERG expressed in HEK293 cells by whole cell voltage patch clamp technique | 2011 | European journal of medicinal chemistry, Oct, Volume: 46, Issue:10
| Biophysical and physicochemical methods differentiate highly ligand-efficient human D-amino acid oxidase inhibitors. |
| AID619921 | Thermodynamic solubility of the compound in phosphate buffer at pH 7.4 after 24 hrs by HPLC analysis | 2011 | European journal of medicinal chemistry, Oct, Volume: 46, Issue:10
| Biophysical and physicochemical methods differentiate highly ligand-efficient human D-amino acid oxidase inhibitors. |
| AID619996 | Oral bioavailability (0 to last) in Swiss mouse plasma at 10 mg/kg | 2011 | European journal of medicinal chemistry, Oct, Volume: 46, Issue:10
| Biophysical and physicochemical methods differentiate highly ligand-efficient human D-amino acid oxidase inhibitors. |
| AID1171397 | Drug metabolism in mouse liver microsomes assessed as glucuronidation of compound measured as compound remaining after 30 mins by LC/MS analysis | 2014 | ACS medicinal chemistry letters, Nov-13, Volume: 5, Issue:11
| Structure-Metabolism Relationships in the Glucuronidation of d-Amino Acid Oxidase Inhibitors. |
| AID619925 | Apparent permeability from apical to basolateral side of MDCK cells expressing MDR1 by LC-MS/MS analysis | 2011 | European journal of medicinal chemistry, Oct, Volume: 46, Issue:10
| Biophysical and physicochemical methods differentiate highly ligand-efficient human D-amino acid oxidase inhibitors. |
| AID619979 | Efflux ratio of permeability from apical to basolateral over basolateral to apical side in human Caco2 cells by LC-MS/MS analysis | 2011 | European journal of medicinal chemistry, Oct, Volume: 46, Issue:10
| Biophysical and physicochemical methods differentiate highly ligand-efficient human D-amino acid oxidase inhibitors. |
| AID1159607 | Screen for inhibitors of RMI FANCM (MM2) intereaction | 2016 | Journal of biomolecular screening, Jul, Volume: 21, Issue:6
| A High-Throughput Screening Strategy to Identify Protein-Protein Interaction Inhibitors That Block the Fanconi Anemia DNA Repair Pathway. |
| AID1798301 | In vitro D-Amino Acid Oxidase Assay from Article 10.1021/jm800200u: \\Synthesis and Biological Evaluation of d-Amino Acid Oxidase Inhibitors.\\ | 2008 | Journal of medicinal chemistry, Jun-26, Volume: 51, Issue:12
| Synthesis and biological evaluation of D-amino acid oxidase inhibitors. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |